Extensive research has displayed the intricate relationship between our endocannabinoid system and the functioning of various organs. Scientific studies have shown they’re far more connected than previously thought, leading to the unveiling of the remedial potential CBD has on these systems.
Plenty of the studies and results published to date suggest for additional research to be conducted on CBD’s efficacy. While its impact on our memory appears to be between positive and inconsequential, scant findings present a counter to the argument. That said, even if the entirety of the tests on CBD and memory proved one way or another, additional research would likely be required for a definitive statement to be determined.
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There is growing evidence that THC is implicated in addiction and cannabis-induced psychosis. CBD, on the other hand, is being researched for a range of therapeutic functions, but the interplay between THC and CBD is not yet well-known.
CBD is further involved in the modulation of different receptors outside the ECS. The serotonin receptors have been implicated in the therapeutic effects of CBD.
The THC only group had decreased connectivity in the salience network, compared to controls, which was rescued by the addition of CBD. The default mode was also disrupted in the THC only group, and this positively correlated with subjective feelings of being "high". These results add to the growing body of literature suggesting that CBD counteracts the effects of THC. So the next time you indulge (legally, please) you may want to have your CBD pen handy.
By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD. In rodent models, CBD effectively blocked the formation of fearful memories. CBD may be an effective strategy to combat PTSD fear memory acquisition because of its direct effects diminishing the severity of traumatic memory. Rat trials also show CBD’s potential in fear memory extinction, demonstrated through a significant decrease in freezing time when re-exposed to an anxiety-inducing situation. Treatment with CBD has also been shown to attenuate contextual memories associated with past experience in murine experiments, showing CBD’s ability to disrupt harmful memories.
Consroe P, Benedito MA, Leite JR, Carlini EA, Mechoulam R. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Castillo A, Tolóna MR, Fernández-Ruizb, J, Romeroa J, Martinez-Orgadoa J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Bergamaschi MM, Queiroz RHC, Chagas MHN, de Oliveira DCG, De Martinis BS, Kapczinski F, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients.
Cannabinol (CBN) is mostly found in aged cannabis plants, because it is produced by the degradation of THC. It has a much lower affinity for the body’s CB1 receptors, but a higher one for CB2 receptors. As a result, CBN doesn’t have too much affect on our brains and has a more pronounced affect on the immune system, research suggests. CBC’s anti-inflammatory properties are among the reasons more experts are showing interest in cannabinoids as medical treatment.